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I was scheduled for neck surgery this week. I really need it, but it was cancelled because of Covidiots, that won't get the F'ing jab. St.Francis is over crowded with covid patients at the moment. Very angry at the moment. I shouldn't say it, but I hope all you anti vaxers just go ahead and die so we can get back to normal.Last edited by Hoop; 12-23-2021, 07:30 PM.Leave a comment:
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IU just halted recruiting for clinical trials. They need the beds and the personnel to address the surge. I never got an email last time that they were doing that and IU has surpassed the fall surge. Not sure how bad it will get but we are on the wrong side of the peak.Last edited by Gamble1; 12-23-2021, 02:57 PM.Leave a comment:
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I am not sure where you are reading that it doesn't target the spike protein? It basically is a manufactured spike peptide.
This is the publication for Nova Vax
They also just announced that they are working on the omicron version of their vaccine.
As for whether or not to get the booster the main point is that antibody protection goes down over time. Doesn't matter if it's natural infection or vaccine. So if it's been over 6 months then it's safe to say that your antibodies are more than likely down.
As for Omicron the mutations will drop how many antibodies work and that doesn't matter if it's a vaccine or natural infection. The point of the booster is to increase the ones that work. So if Omicron makes 20% of your antibodies not work then take the predicted antibdody titers and drop them by 1/5th.
I would encourage anyone to do a risk assessment of the people they plan on interacting with for the next couple of months. If they are unvaccinated or are immune compromised or plan on getting pregnant or have some serious health concerns then get boosted if you want to protect their health.
Me personally I got boosted so I could protect my extended family and I know they will authorize another booster at a specific interval in the future. So in March when Omicron is the predominant variant the first booster directed at that variant I will qualify for and so will my family members.
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We started seeing an uptick in Covid cases again about 2.5 weeks ago. Several severely ill patients but still not nearly as acute as it was a year or so ago. However to be fair one of the reasons our hospitals are so full at the moment is that all of our norther district hospitals have been inundated with admissions from Michigan. We are seeing an influx of patients being transferred down from a line north of Peru because the majority of the hospitals up there have overflow Michigan patients.
Don't take that as me saying we don't have a full serving here, we have a lot believe me, but the North in particular is getting a lot of their patients from MichiganLeave a comment:
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I just seen that the Moderna Booster is a half dose (50 micro grams), and boosts the antibody titers by 37x. Should offer strong protection against Omicron. If I get a booster (not sure I need one with my Covid history and being fully vaccinated with Moderna). Moderna booster looks like a good candidate. But I am actually hoping for the NOVA VAX version to come out here soon, I read that it doesn't target the spike protein but rather some other elements of the virus that do not mutate as much.Leave a comment:
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Vaccine Omicron update.
This is the most important line.
So like I said before if they used the full binding domain of the spike protein then the mutations would only reduce the vaccine efficacy by a small percentage.- increases the neutralizing antibody titers by 25-fold compared to two doses against the Omicron variant; titers after the booster dose are comparable to titers observed after two doses against the wild-type virus which are associated with high levels of protection
- As 80% of epitopes in the spike protein recognized by CD8+ T cells are not affected by the mutations in the Omicron variant, two doses may still induce protection against severe disease
We still need to see the data on the comparison of the two groups but this is really encouraging.
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So some good news.
The FDA and companies are talking about a omicron specific booster. In the best case scenario the future booster would be to a site that isn't heavily mutated but that does not me not mean it won't mutate in that area in the future. I can not see them changing the area of the spike protein that they are targeting but it is plausible that they do that.
The bad news is that the early data from south africa is saying natural immunity doesn't prevent reinfection.
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Yeah it's hard for me to understand how a person could keep getting hives if they are no longer exposed to the allergen. The only explanation I could come up with is if the fat aka PEG is being stored or not cleared. This is the stuff they use to help protect the mRNA and is often called lipid nano particles.
The PEG the vaccines use are not the same as what is found in other medications or products but the basic clearance of this stuff maybe an issue for some people.
It would not be hard to find out if she is allergic to PEG and if you are concerned the doctor may run an allergen screen for you. That maybe helpful to know in the future to avoid the same reaction with other medication.
Miralax is a form of PEG. Amoxicllin tablet form has PEG in it but I don't believe it is in oral suspension.
https://www.science.org/content/arti...rgic-reactions
https://dailymed.nlm.nih.gov/dailyme...nium%20Dioxide.
Last edited by Gamble1; 12-03-2021, 07:19 PM.Leave a comment:
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Thanks for you response! Its very helpful.
Her hives seem like the had started to recede this morning, so hopefully it will be a very short thing for her. My daughter is actually on Claritin pretty much daily during the fall and early winter due to seasonal allergies that give her a runny nose and post nasal drip cough.
I had discovered a Reddit thread where some folks were documenting how they got hives after their first dose. Many of them were dealing with on going hives for many months. Their hives would disappear within an hour after taking an anti-histamine, but be back just as bad the next day. One person said it took 6 months for them to totally clear up without the help of zyrtec. You can imagine my gut reaction as a parent....Leave a comment:
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If she got hives with this one I would bet it is likely she gets it with the second dose. I personally wouldn't worry about getting the second dose as the antibody titer that gets generated from an infection and one dose of the vaccine is pretty strong.
It is also not just about antibodies but also making the Tcells ready to recognize the virus. She will also have this strong protection as well.
If she does end up getting or needing to get the second dose from what I have read a person can be on anti histamine medication before the vaccine shot. Consult your doctor of course but I had to look into to this for my mother in law who is on antihistamine daily. Like most things this may change with more data.
Glad she will be okay in the end though.
Last edited by Gamble1; 12-03-2021, 09:38 AM.Leave a comment:
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Yup he prescribed Zyrtec and said they will probably go away in a few days, but to expect the hives to get much worse before they start to fade.
Since she has already had Covid at the beginning of the year the doctor recommended that she not receive the 2nd dose due to the allergic reaction and to just think of this as her Covid Booster.
I am wondering what would happen if she did get the 2nd dose. I wasn’t at the appointment so I didn’t get a chance to ask. I have read many stories now about young adults who got rashes or hives on their first dose but had no adverse reaction on the 2nd dose. I suppose it could go either way though, as in having an even worse reaction and full on anaphylaxis?
the last time she has hives like this was when she was on a course of amoxicillin.Leave a comment:
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Sorry to her she got a reaction like that.
From the cdc website
https://www.cdc.gov/coronavirus/2019...-reaction.html
It most likely is a mild side effect. A severe case is really rare as in 5 per million rare.
A simple anti histamine will probably do the trick and it won't hurt the vaccine efficacy.
I am curious what the doctor gives as a treatment.Last edited by Gamble1; 12-02-2021, 07:26 PM.Leave a comment:
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If a poster is bothering you, and an administrator has not or will not deal with that poster to the extent that you would prefer, you have a powerful tool at your disposal, one that has recently been upgraded and is now better than ever: The ability to ignore a user.
When you ignore a user, you will unfortunately still see some hints of their existence (nothing we can do about that), however, it does the following key things:
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Rule #6And I would put the pasted article in quotes like this.
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We prefer self-restraint and/or modesty when making jokes or off topic comments in a sports discussion thread. They can be fun, but sometimes they derail or distract from a topic, and we don't want to see that happen. If we feel it is a problem, we will either delete or move those posts from the thread.
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Do not advertise anything without talking about it with the administrators first. This includes advertising with your signature, with your avatar, through private messaging, and/or by making a thread or post.
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