I-69 would make the trip to E'ville about 2.5 hours.
If you take the Louisville route(I65 to I64 and over) its about 5 hours.
If you take the terrehaute route(I 70 to Hwy 41 and down) its about 4 hours.
If you take the direct no interstate route(Hwy 67 to Hwy 57 and down) its about 3.5 hours.
Think of the commercial real estate opportunities along a undeveloped I-69 Mr. Real estate agent...