I will respond later with my thoughts when I have more time and not on my phone. I'm a board certified forensic toxicologist by trade. Didn't want to disclose that earlier, but thought I should now. I've testified in court on many occasion about chain of custody, sample storage, tox results interpretation, metabolism/excretion of drugs, etc.
Being this is MLB testing that is collectively bargained, it is a little different than what would end up in the court system. I could easily see this in a court system and have it explained thoroughly what occurred and that the specimen was truly intact with all seals unbroken and the testing has a good possiblity of being rendered as legitimate and true. I've testified in many courtrooms about the chain of custody and the speicmen storage procedures.
In biological specimens, parent drugs do not get enhanced as the degradation process (through storage, temperature, etc.) occurs. Metabolites could possibly form. As an example, the nitrobenzodiazepines are inherently unstable in biological matrices (blood, urine). At room temperature, Klonopin (parent drug Clonazepam) will degrade to its metabolite (7-aminoclonazepam) over the period of 24-48 hours. It does not work the other way around. The same goes for another benzodiazepines (Flunitrazepam (Rohypnol) to its 7-amino metabolite).
Amphetamines (i.e. Adderall, Ecstacy, Methamphetamine) and LSD are detectable for 1-5 days.
Barbiturates (i.e. Fiorinal, Seconal) are detectable for 1-30 days depending on which specific barbiturate it is.
Benzodiazepines (i.e. Valium, Xanax, Klonopin), Buprenorphine (Suboxone), and Methadone are detectable for 1-10 days depending on the individual drug.
Cannabinoids (Cannabis, Marijuana) is detectable for 1-4 days in the urine of an occasional user or 1-30 days in the urine of a frequent user.
Cocaine is detectable for 1-4 days.
Alcohol (Ethanol) is detectable for 1-24 hours; ethanol metabolites are detectable for 1-3 days.
Opiates/Opioids (i.e. Codeine, Morphine, Heroin, Vicodin, Oxycodone) are detectable for 1-4 days.
Man, that's a lot of good info.
Also, I would assume that Braun's metabolism would be off the charts since he's a pro athlete and would be near the low end of your time windows above.
Collector in Braun case: I followed protocol
A man identifying himself as the collector who took Ryan Braun's urine samples last fall said he followed the same protocol with the Milwaukee Brewers slugger as he had with hundreds of previous samples.
In an email sent Tuesday to ESPN The Magazine's Buster Olney and other media outlets, Dino Laurenzi Jr. said he issued the statement "to set the record straight" about his role in testing Braun, whose 50-game suspension under baseball's drug policy was overturned Thursday.
Laurenzi said that at the time of the test, he obtained a signature from the NL MVP, stipulating that the samples were capped and sealed in his presence.
"This situation has caused great emotional distress for me and my family. I have worked hard my entire life, have performed my job duties with integrity and professionalism, and have done so with respect to this matter and all other collections in which I have participated," Laurenzi said, directing all further requests for comment to his lawyer.
Laurenzi's lawyer, Boyd M. Johnson III of WilmerHale, said Laurenzi would have no further comment.
"Mr. Laurenzi just wanted to set the record straight, and now he has done exactly that," Johnson said in a statement.
Braun tested positive in October for elevated testosterone, and ESPN's "Outside The Lines" revealed the positive test in December. His case marked the first time a baseball player has successfully challenged a drug-related penalty in a grievance.
Friday, Braun proclaimed his innocence at a news conference. He said the collector, whom he did not identify by name, had kept the samples for 44 hours in his home, believing that the FedEx office he was to use to ship the samples for testing was closed.
Braun said Friday that at least five FedEx locations within 5 miles were open until 9 p.m. ET and there also was a 24-hour location. He said the sample wasn't left with FedEx until 1:30 p.m. on Oct. 3.
Braun said because of the delay, the testing was "fatally flawed."
"I don't honestly know what happened to it in that 44-hour period," he said.
Tuesday, Laurenzi said he was following protocols set by Comprehensive Drug Testing, his employer, in keeping the samples until they could be shipped. He said the samples never left his custody and that no one other than his wife was in his home while the samples were stored.
"Given the lateness of the hour that I completed my collections, there was no FedEx office located within 50 miles of Miller Park that would ship packages that day or Sunday. Therefore, the earliest that the specimens could be shipped was Monday, October 3," Laurenzi said.
"In that circumstance, CDT has instructed collectors since I began in 2005 that they should safeguard the samples in their homes until FedEx is able to immediately ship the sample to the laboratory, rather than having the samples sit for one day or more at a local FedEx office," Laurenzi said in the statement.
Laurenzi said in the statement that he stored the samples in a "FedEx Clinic Pack in a Rubbermaid container in my office which is located in my basement. My basement office is sufficiently cool to store urine samples."
He added: "The protocol has been in place since 2005 when I started with CDT and there have been other occasions when I have had to store samples in my home for at least one day, all without incident."
Laurenzi said he has been a collector for Comprehensive Drug Testing since 2005, conducting more than 600 collections since then, in addition to postseason collections for five major league teams.
"I followed the same procedure in collecting Mr. Braun's sample as I did in the hundreds of other samples I collected under the program," Laurenzi said of his collection of Braun's urine samples on Oct. 1.
"I sealed the bottles containing Mr. Braun's A and B samples with specially numbered, tamper-resistant seals, and Mr. Braun signed a form certifying, among other things, that the specimens were capped and sealed in his presence and that the specimen identification numbers on the top of the form matched those on the seals."
Although MLB officials would not comment on the record, sources told ESPN legal analyst Lester Munson they are still convinced that the sample tested came from Braun, and that the positive test result was correct. They emphasized that the FedEx package that arrived at the Montreal laboratory handling the test was sealed three times with tamper-proof seals -- one on the box, one on a plastic bag inside the box, and one on the vial that contained the urine.
I think the real lesson here is that the sampling and testing company needs better handling and storage procedures that both sides agree to. Maybe they have been fine up until now, but the arbitrators decision changes the game.
Interesting speculation by a guy from WADA on the Gottlieb show yesterday: he said Braun could have been sabotaged by someone rubbing a cream with synthetic testosterone on his body (no jokes please). Far-fetched, but strange that a WADA guy would bring it up.
I bet it would suck to be outside in high-90 degree heat and have a herpes flare-up inside those pants and cup.